An Introduction of MCE Membrane Filter

MCE membrane is made of refined nitrocellulose and added with the appropriate amount of cellulose acetate, acetone, n-butanol, ethanol, etc. It is hydrophilic, non-toxic, and hygienic. The filter is mainly used for filtering aqueous solutions, so it is also called a water-based membrane, which is flammable and should be sealed to prevent moisture and fire during storage.

MCE membrane filters have a higher protein binding ability than Cellulose Acetate membrane filters; they cannot be used for protein extraction; high porosity makes it have a faster flow rate ratio; suitable for base water samples. MCE filter membrane is mostly used in the fields of biology and medicine, for the clarification of aqueous solutions and filtration of sterilized gas particles and bacteria; filtration of alcohol and particulate bacteria. Water syringes that require autoclaving in the pharmaceutical industry, large infusions to filter out particles; sterilization of heat-sensitive drugs (biochemical preparations such as insulin ATP, coenzyme A, etc.), use a 0.45 μm filter (or 0.22); analysis and determination of particulate and oil intolerant substances, and determination of water pollution index; it is also used in scientific research departments such as somatic cell hybridization and mitochondrial complementation prediction of hybrid vigor.

Characteristics of MCE Membrane Filters:

  1. Composition:
    • MCE membranes are composed of a blend of cellulose acetate and cellulose nitrate. The combination provides enhanced strength, low protein binding, and good chemical resistance.
  2. Pore Size Range:
    • MCE membranes are available in a range of pore sizes, making them suitable for applications with diverse particle sizes. Common pore sizes range from 0.1 µm to 10 µm.
  3. Hydrophilic Nature:
    • MCE membranes are inherently hydrophilic, allowing for easy wetting and promoting the passage of aqueous solutions through the membrane.
  4. Low Protein Binding:
    • The low protein binding properties of MCE membranes make them suitable for applications involving biological samples, as they minimize the adsorption of proteins.
  5. Chemical Compatibility:
    • MCE membranes exhibit good chemical compatibility with a variety of solvents and solutions, making them versatile for different filtration processes.
  6. Temperature Resistance:
    • These membranes generally have good temperature resistance, allowing for filtration processes involving both cold and hot solutions.

Main applications of MCE Membrane Filter

1. Fine filtration of high-purity water in the electronics industry.
2. Analysis and determination of particles and oil insoluble in solution, and determination of water pollution index.
3. Applied to scientific research departments such as somatic cell hybridization and mitochondrial prediction of heterosis.
4. Medicine and health, the detection of C-AMP, C-GMP, and bloodworm in human body fluids by the MCE filter membrane, detection of coli-groups in drinking water, surface water, and well water.
5. If the pharmaceutical industry requires autoclaving, water injections, large infusions, Chinese medicine extraction, and beverage filtration to remove particulates can improve the intrinsic quality of medicines and the pass rate of sterility for the sterilization of heat-sensitive drugs (biochemical preparations such as insulin ATP and coenzyme A). Antibacterial thin membrane method for sterility test, using 0.45-micron filter membrane(or 0.3 microns, 0.2-micron filter membrane).

To learn more about MCE filter membranes, please click About the Mixed Cellulose Ester Filter Membrane

hydrophobic ptfe membrane filter 0.45 Disc Vacuum Microfiltration Membrane hydrophilic ptfe membrane filter

Matters needing attention of MCE Membrane

1. The membrane filters must be wet when filtering the liquid. If the filter membrane becomes dry due to disinfection, it must be wetted with sterile water. If the wetting does not affect the flow rate, the filter membrane of all appliances must be disinfected. Then, sterilization and filtration in a sterile room should be carried out in strict accordance with the sterilization operation procedures, with nominal pore diameters of 0.45 micrometers, 0.3 micrometers, and 0.2 micrometers used. E. coli uses a nominal pore diameter of 0.65 micrometers.

2. The membrane is resistant to high temperatures of 120 degrees, flammable, acid and alkali resistant, and solvent resistant. It is only suitable for aqueous solutions (PH2-10), oils, air, fruit juices, etc. Before use, you must understand whether the filter substance is influential to the membrane.

3. When the retentate is below 0.025 microns, it is not suitable to use a microporous membrane for filtration. It only has an adsorption effect on the heat source virus and cannot be completely removed.

4. When using the filter, the liquid material entering the filter should let the original air out, otherwise, it will affect the filtration speed.

5. Use natural pressure, pressurization, vacuum, and negative pressure to prevent the bacteria and particles in the air from polluting the filtrate when vacuuming. With pressurized filtration, faster filtration speed, faster pressure, faster filtration speed. We should consider whether the main body of the filter is intact when the pressure is high. Generally, IT does not exceed 0.3MPa / c㎡. Many companies use the position difference, but not too low, otherwise, the flow rate will become slow.

6. Put the filter in the container, soak it in distilled water at about 70℃ and let it all wet for several hours (about 4 hours), then rinse it with distilled water once before use.

Do you know PVDF vs PTFE? Please click here PVDF VS PTFE, Membrane Filtration Principle