Application and Use Points of Sterilized Microporous Membrane Filter

Application of Sterile Microporous Membrane

Sterilized microporous membrane filters find widespread applications in various industries, particularly in laboratory, pharmaceutical, and food processing settings. These filters are designed to remove microorganisms and particles from liquids and gases, ensuring aseptic conditions. Here are some common applications of sterilized microporous membrane filters:

  1. Biological and Microbiological Research:
    • Sterilized membrane filters are crucial in microbiological research and testing. They are used to filter microbial cultures, media, and other solutions to maintain sterile conditions and prevent contamination.
  2. Pharmaceutical Manufacturing:
    • In the pharmaceutical industry, microporous membrane filters are employed during the production of drugs and sterile pharmaceutical products. They are used to filter liquids and gases, ensuring the removal of bacteria and particles that could compromise the quality and safety of the final product.
  3. Food and Beverage Industry:
    • Sterilized membrane filters play a key role in the food and beverage industry. They are used for filtering beverages, syrups, and other liquid products to ensure they are free from microbial contaminants.
  4. Water Filtration:
    • Microporous membrane filters are used for water purification and filtration. They help remove bacteria, fungi, and particulate matter from water sources, making the water suitable for various applications, including laboratory work and industrial processes.
  5. Air Filtration:
    • In controlled environments such as cleanrooms and laboratories, sterilized membrane filters are used in air filtration systems to maintain sterile conditions and prevent the introduction of airborne contaminants.
  6. Environmental Monitoring:
    • Sterilized membrane filters are employed in environmental monitoring to analyze air and water samples for microbial contamination. This is especially important in environmental testing laboratories.
  7. Biopharmaceutical Processing:
    • In the production of biopharmaceuticals, sterile filtration is crucial to maintain the integrity of the product. Microporous membrane filters are used in various stages of biopharmaceutical processing, including the filtration of cell cultures and final product formulations.
  8. Vaccine Production:
    • The production of vaccines requires strict control of microbial contaminants. Sterilized membrane filters are used in the filtration of vaccine components and final formulations to ensure the safety and efficacy of the vaccine.
  9. Laboratory Filtration:
    • In laboratory settings, microporous membrane filters are used for various applications, including the sterilization of culture media, filtration of samples for analytical testing, and other processes requiring aseptic conditions.
  10. Oil and Gas Industry:
    • Sterilized membrane filters are utilized in the oil and gas industry for the filtration of gases and fluids in critical processes to prevent microbial contamination and maintain the integrity of equipment.

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1. Measuring the bubble point pressure can indicate the pore size of the sterilized microporous filter membrane, which is closely related to the quality of the filtered liquid, and it is also a means to ensure the quality of the sterilized microporous filter membrane. The membrane filter sterilization used needs to be soaked in water for injection at about 70°C for about one hour in advance. Pour out the water and soak in warm water for injection overnight for later use. Take it out before use, rinse it with water for injection, and then put it into the filter for use. When installing, pay attention to prevent the microfiltration membrane from crooked and leaking.

2. In order to protect and extend the service life of the filter membrane, you can use the same size filter paper or silk cloth on the filter membrane to prevent the filter membrane from rupturing.

3. The pore size of the sterile microporous filter membrane is cone-shaped. The smooth side has a small pore size as the front side; the rough side has a large pore size as the backside. When installing, the front side should face down and the backside up, otherwise the pore size will be easily blocked by impurities.

Then affect the filtration rate. When the temperature is low, soak the treated filter membrane in water for injection at the same temperature as the drug solution for 10 minutes, which can avoid the rupture of the membrane due to the drop in tensile strength of the filter membrane due to the temperature difference.

Points to Note When Using Sterile Microporous Membrane Filter

1. Fix a 16-gauge syringe on the skin tube head of the exhaust pipe of the filter holder, and use a water stop clip to control it to avoid excessive exhaust pressure and speed from causing the filter membrane to rupture.

2. Do not sterilize the filter holder together with the filter membrane, otherwise, the microporous membrane filter will become brittle and crease due to thermal expansion and contraction.

3. After use, the sterilized microporous filter membrane is soaked in water for injection to prevent drying, but it should not be soaked for too long. The sterilized microporous filter membrane that has been dehydrated and dried cannot be used.

4. According to the concentration and viscosity of the drug solution, sterile microporous membranes with different pore diameters should be selected.

5. If you find small holes or cracks in the sterilized microporous filter membrane, you can use the unused broken filter membrane, wash it and dry it, then tear it into a small cup with a small amount of acetone, and stir it into Paste mucus, drop the mucus on the small cracks or small holes of the flat filter membrane. It should not be too much. The mucus should be covered and slightly larger. After it dries, you can continue to use it without affecting it.

6. When using a multi-stage filtration device with coarse filtration and then fine filtration during infusion filtration, sterile microporous membranes can be used for fine filtration afterward, preferably pressurized, decompressed, and azimuthal static pressure filtration.

In order to protect and extend the service life of the filter membrane, filter paper or silk cloth of the same size can be used (the silk cloth should be boiled with a mass concentration of 20 g·L-1 sodium sulfonate solution for about 30 minutes, and then cleaned with water for injection). On the filter membrane, prevent the filter membrane from rupturing or pollution.