Membrane Separation Technology in Medicine Preparations
At present, membrane separation technology has been widely applied in the medical industry, especially the preparation of oral agents and injections of traditional Chinese medicines. Thus, customers need to know more details about this technology.
Overview of the Technology
Under the help of various permeable filter membranes, membrane technology provides engineering strategies to transport selected substances between two different portions.
To speak in a general way, filter membranes technology is utilized in processing separating gas or fluid streams in a mechanical way.
Technical Features of membrane filter
Firstly, membrane separation technology can be used to differentiate and concentrate on heat-sensitive substances in a normal temperature environment. It has a very low energy consumption rate while providing a high separation efficiency.
It could retain the active ingredients during the extraction process of the drug. Besides, it can maintain a superior environmental protection effect. It can realize the automatic separation of substances, which is easy for the operators to implement and carry out.
The filter membranes are easily contaminated, such as the blocked pores phenomenon or appearance of the formed adhesion layer. For the separation of traditional Chinese medicine, it is necessary to maintain the pore diameter of the medicine in the range of 1 to 5 nanometers.
Then, the medicine should be treated by medium filtration method, like the filter paper or talcum powder. The efficiency and quality of the separation can be greatly improved.
Meanwhile, the filter membrane could also be well protected. Moreover, to effectively alleviate the concentration polarization, the solute concentration on the surface of the membrane should be reduced. In the process of solving this problem, there are two kinds of methods to reduce the viscosity of the Chinese medicine liquid, magnetic stirring, and pulse flow method.
Applications of filter membranes
Membrane processes do not require heating so that it consumes less energy than traditional thermal separation technology named distillation, sublimation, and crystallization. Due to its purified physical processing ability, both permeate and retentate portions can be involved.
Specifically, cold separation with the membrane is universally applied to the food, biology and pharmaceutical industries. Moreover, membranes make some separations be realized, which is not imaginable with the thermal methods.
Two Basic Models(to distinguish mass transfer)
In currently available filter membranes, there are two transporting approaches occur successively, especially existing in the ultra-filtration.
1. The solution-diffusion model
With the solution-diffusion model, transporting happens merely in diffusive condition.
*Be careful that the demanded component has to be dissolved in advance.
2. The hydrodynamic model
To operate hydrodynamically, transportation is accomplished in a convective environment, which requires smaller pore dimensions than other two isolated components’ diameters.
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